Mnemonics: Fc Receptors

Author: V. Dimov, M.D., Allergist/Immunologist and Assistant Professor at University of Chicago
Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology


An antibody has Fab (fragment, antigen-binding) and Fc (fragment, crystalizable) regions. Fc receptors bind to the Fc region. Image source: Wikipedia, public domain.


Fc receptor interaction with an antibody-coated microbial pathogen. Image source: Wikipedia, public domain.

Fc gamma receptors for IgG: CD 16, 32, 64 (double).

Fc gamma receptors for IgG (CD 16, 32, 64) are labeled in "reverse" order:

CD 16 - FcR III - low-affinity
CD 32 - FcR II - intermediate-affinity
CD 64 - FcR I - high-affinity

CD 16 and CD 56 are present on NK cells.

Fc II receptors:
CD 32 -Fc gamma II
CD 23 - Fc epsilon II, Fc receptors for IgE

Downregulation of IgG

T
Thirty-two, CD 32
Two, FcR gamma II
Turns downs (down regulates) IgG


The uptake of bacteria by phagocytes is an active process, which requires the triggering of specific receptors on the phagocyte. Fc receptors, which bind antibody-coated bacteria, are one of the receptors capable of triggering phagocytosis. This video is from: Janeway's Immunobiology, 7th Edition Murphy, Travers, & Walport. Source: Garland Science.

References

Fc Receptors
Fc receptor, from Wikipedia, the free encyclopedia.

Published: 04/18/2009
Updated: 05/21/2009