Mnemonics: Toll-like receptors (TLRs)

Author: V. Dimov, M.D., Allergist/Immunologist and Assistant Professor at University of Chicago
Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology


The curved leucine-rich repeat region of toll-like receptors, represented here by TLR3. Image source: Wikipedia.


Signaling pathway of toll-like receptors. Dashed grey lines represent unknown associations. Image source: Wikipedia.

TLR 2
Two
TB and other mycobacteria

TLR4 (for LPS)
CD14

TLR 5
Five
Flagellin
Flagelated bacteria

TLR 7
Seven
SS RNA

TLR 9
Nine
Nonmethylated
Nucleotide motifs - CpG

TLR 3
Three is "Free" of MyD88

What are the intracellular TLRs?

TLR 3, 7, 8, and 9 are in the intracellular compartment and detect nucleic acids.

What is MyD88?

MyD88 is an adapter protein that plays a role in TLR signaling. MyD88 is involved in all TLR-signaling pathways except TLR 3.

Related reading

Nickel allergy tracked to a single receptor - Toll-like receptor 4 (TLR4) http://goo.gl/PZic

Published: 05/01/2009
Updated: 08/02/2014