Author: V. Dimov, M.D., Fellow, Creighton University Division of Allergy & Immunology
Reviewer: S. Randhawa, M.D., Fellow, LSU (Shreveport) Department of Allergy & Immunology
CD1 is an MHC-like molecule that presents lipid molecules. There are 5 subsets - CD1a, b, c, d, e
CD1 glycoproteins can be classified primarily into 3 groups which differ in their lipid anchoring:
- CD1a, CD1b and CD1c (group 1 CD1 molecules) are expressed on cells specialized for antigen presentation (APC).
- CD1d (group 2 CD1) is expressed in a wider variety of cells. Group 2 CD1 molecules activate a group of T cells, known as Natural killer T cells.
- CD1e is an intermediate form, expressed intracellularly, the role of which is currently unclear.