Reviewer: S. Randhawa, M.D., Fellow, LSU (Shreveport) Department of Allergy & Immunology
Carcinoembryonic antigen (CEA) is a glycoprotein involved in cell adhesion. It is normally produced during fetal development and its production stops before birth. CEA not present in the blood of healthy adults.
CEA is also known as CD66. It belongs to the immunoglobulin superfamily.
Adhesion Molecules
Overview of adhesion molecules, 3 groups remembered by the mnemonic SIS.
Adhesion molecules, 3 groups = SIS:
Selectins
Integrins
Superfamily Ig
CEA is elevated in individuals with colorectal carcinoma and gastric carcinoma.
Arcitumomab is a murine (mouse) monoclonal antibody which recognizes carcinoembryonic antigen (CEA).
Ig Superfamily = cell adhesion molecules (CAM)
VIP:
VCAM (vascular cell adhesion molecule)
ICAM (intercellular adhesion molecule)
PECAM (platelet-endothelial cell adhesion molecule)
Intercellular adhesion molecule 2 (ICAM 2). Image source: Wikipedia.
References
Carcinoembryonic antigen. Wikipedia.
Adhesion Molecules
Cluster of differentiation (CD) of leukocytes
Published: 06/01/2009
Updated: 06/02/2009
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