Mnemonics: Chemokines

Author: V. Dimov, M.D., Allergist/Immunologist and Assistant Professor at University of Chicago
Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology

CXC chemokines

P

Positive ELR (glutamic acid-leucine-arginine) chemokine CXC

PMN migration

CXCL10

1 or I

CXCL

10

IP-10

Interferon-induced T migration

Chemokines that guide T and B cell migration within lymph nodes

CXCL13 (BCA-1) - binds to CXCR5 - causes B cell migration into follicles

CCL19 (MIP-3β/ELC) and CCL21 (SLC) - both bind to CCR7 - cause T cell and dendritic cell migration into parafollicular zones of lymph nodes

Mnemonic

CXCL13 binds to CXCR5 - causes B cell migration into follicles
1 + 3 = 4, 5 (binds to CXCR5)

CCL19 and CCL21 bind to CCR7 - cause T cell cell migration into parafollicular zones of lymph nodes
9 - 2 = 7 (bind to CCR7)

What chemokine attracts naïve B cells to lymph nodes?

CXCR5. CXCL13 binds to CXCR5.

What chemokine attracts naïve T cells to lymph nodes?

CCR7. CCL19 and CCL21 bind to CCR7.

Published: 05/20/2010
Updated: 09/02/2010