Reviewer: S. Randhawa, M.D., Fellow, LSU (Shreveport) Department of Allergy & Immunology
CD127 is the IL-7 receptor alpha chain.
Interleukin 7 (IL-7)
Interleukin 7 (IL-7) is a hematopoietic growth factor secreted by the stromal cells of the bone marrow and thymus. IL-7 stimulates the differentiation of multipotent (pluripotent) hematopoietic stem cells into lymphoid progenitor cells (as opposed to myeloid progenitor cells where differentiation is stimulated by IL-3). IL-7 stimulates proliferation of all cells in the lymphoid lineage (B and T lymphocytes and NK cells). A defect in IL-7RA leads to SCID (T-/B+/NK+).
Interleukin-7 receptor (IL7R)
Interleukin 7 receptor (IL7R) is also known as CD127 (Cluster of Differentiation 127) is a type I cytokine receptor. Type I cytokine receptors are transmembrane receptors expressed on the surface of cells that recognize and respond to cytokines with four α-helical strands.
Type I cytokine receptors are mediated through JAK/STAT and bind: IL-2, 3, 4, 5, 6, 7, 9, 10, 12, 13, 15, GM-CSF.
Key steps of the JAK-STAT pathway. Image source: Wikpedia, public domain.
IL7R plays a critical role in the V(D)J recombination during lymphocyte development. A defect in IL-7RA leads to SCID (T-/B+/NK+).
Thymic stromal lymphopoietin (TSLP)
Thymic stromal lymphopoietin (TSLP) signals through a heterodimeric receptor complex composed of the TSLP receptor and the IL-7R alpha chain. Some researchers have classified TSLP as a "master regulator" of the Th2 response due to overexpression of the cytokine in pulmonary tissue and skin cells result in Th2-induced asthma and dermatitis.
TSLP is produced mainly by non-hematopoietic cells as fibroblasts, epithelial cells and different types of stromal cells.
Anti-TSLP is a potential new therapeutic target in asthma.
References
Cluster of differentiation, Wikipedia.
List of human clusters of differentiation (CD), Wikipedia.
TSLP calms inflammation. The Journal of Experimental Medicine, Vol. 206, No. 3, 493, 2009.
TSLP, Wikipedia.
Interleukin-7 receptor, Wikipedia.
Interleukin 7, Wikipedia.
Cluster of differentiation (CD) of leukocytes
Thymic stromal lymphopoietin (TSLP) is associated with allergic rhinitis in children with asthma http://goo.gl/c0vzJ
Published: 05/18/2009
Updated: 01/18/2011
No comments:
Post a Comment