Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology
Source: Macrophages, T cells (mainly regulatory T cells)
IL-10 binds to a type II cytokine receptor, with Jak1 and Tyk2, Janus family kinases, which induce STAT3 signaling molecule.
(click to enlarge the image)
IL-10 effects
Macrophages, dendritic cells: inhibition of IL-12 production and expression of costimulators and class II MHC molecules
IL-10 has numerous functions:
- Inhibits eosinophil survival
- Inhibits IL-4 induced IgE synthesis
- Enhances IgG4 isotype switching
- Main inhibitory cytokine produced by T-reg cells in SCIT
In normal volunteers, IL-10 decreases CD4+ and CD8+ T cells, T-cell proliferation and endotoxin-driven TNF and IL-1beta production.
References
Recombinant human IL-10 currently being tested in RA, IBD, psoriasis, transplantation and hepatitis C. Chernoff, A. E. et al. A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses. J. Immunol. 154, 5492–5499 (1995).
(click to enlarge the image)
IL-10 effects
Macrophages, dendritic cells: inhibition of IL-12 production and expression of costimulators and class II MHC molecules
IL-10 has numerous functions:
- Inhibits eosinophil survival
- Inhibits IL-4 induced IgE synthesis
- Enhances IgG4 isotype switching
- Main inhibitory cytokine produced by T-reg cells in SCIT
Trials
In normal volunteers, IL-10 decreases CD4+ and CD8+ T cells, T-cell proliferation and endotoxin-driven TNF and IL-1beta production.
References
Recombinant human IL-10 currently being tested in RA, IBD, psoriasis, transplantation and hepatitis C. Chernoff, A. E. et al. A randomized, controlled trial of IL-10 in humans. Inhibition of inflammatory cytokine production and immune responses. J. Immunol. 154, 5492–5499 (1995).
Neonatal BCG vaccination induces IL-10 production by CD4(+) CD25(+) T cells. http://goo.gl/grZJ
Published: 04/09/2010
Updated: 08/09/2010
Published: 04/09/2010
Updated: 08/09/2010
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