Interleukin-9 (IL-9)

Author: V. Dimov, M.D., Allergist/Immunologist and Assistant Professor at University of Chicago
Reviewer: S. Randhawa, M.D., Allergist/Immunologist and Assistant Professor at LSU (Shreveport) Department of Allergy and Immunology

Source: Th2 cells.

Receptors: Receptors for IL-2, IL-4, IL-7, IL-9, IL-15, and IL-21 contain γ chain, which is affected in X-linked SCID.


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IL-9 effects

Stimulates cell proliferation and prevents apoptosis.

Trials

Blocking IL-9 reduces airway hyperresponsiveness in mice. Phase I trials of IL-9 mAb (MEDI-528) completed. Phase II trials in progress for treating moderate to severe, persistent asthma.

References

http://www.medimmune.com/pipeline/pipeline_phase2_detail.asp. 'Byrne, P. et al. A single dose of MEDI-528, a monoclonal antibody against interleukin-19, is well tolerated in mild and moderate asthmatics in the phase II trial MI-CP-138. Chest 132, 478 (2007).

Published: 04/09/2010
Updated: 08/09/2010